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These amino acids and their metabolism are linked to the synthesis of a variety of secondary metabolites, a subset of which are involved in numerous anabolic pathways responsible for the synthesis of pigment compounds, plant hormones and biological polymers, to name a few

10.1007/s12640-017-9812-z Neurotox

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Gut-derived TMAO induces apoptosis by increasing intracellular mROS levels and further promoting NLRP3 assembly activation, with the underlying mechanism being the regulation of the intracellular mROS-NLRP3 axis to activate cytokinesis and release inflammatory factors, thus promoting DKD (Yi et al., 2023)

However, 10H-PTZ itself 12 or complexed with other molecules (such as 10-carboxamide or Donepezil) also showed neuroprotective effects in Parkinsons disease (PD) 13,14 and Alzheimers disease (AD), also exerting brain protection from oxidative stress 15,16,17