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PD patients exhibit pronounced BBB dysfunction, evidenced by heightened leakage, notably in the substantia nigra and striatum pivotal to the disease's pathology [218, 219]

While GHK-Cu delivers copper in a chelated form that prevents oxidative damage, extended continuous use could theoretically affect copper homeostasis

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"Designing Formulation Strategies for Enhanced Stability of Therapeutic Peptides in Aqueous Solutions: A Review." Pharmaceutics , 2023

Hippocampal neurons transfected with mRFP-P-actin were treated with vehicle (PBS), 10 -12 M Nlel-AnglV, as a positive control, or various concentrations for several stabilized analogs for 5 days in culture or for 30 minutes prior to fixation on day in vitro 12 (DVI12)