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You may have heard of mast cell activation syndrome (MCAS), a condition where mast cells release excess histamine and other inflammatory molecules into the body, causing various symptoms

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These processes were identified as being closely associated with the expression of genes such as glyceraldehyde-3-phosphate dehydrogenase ( GAPDH ), lactate dehydrogenase A ( LDHA ), glutathione peroxidase 1 ( GPX1 ), and 1,4-alpha-glucan branching enzyme 1 ( GBE1 )

Notably, the adverse effects caused by metformin therapy for adolescent patients with PCOS, especially gastrointestinal side effects, need to be a concern, as they may affect their quality of life and treatment adherence

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