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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

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He received his doctorate in naturopathic medicine from Bastyr University

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SVKCR2 cells (human male) were grown in DMEM containing 10% fetal bovine serum, 2 mM L-glutamine, 100 U/ml penicillin, 100 g/ml streptomycin, 10 ng/ml cholera toxin and 400 g/ml G418 46