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Concerns about adverse effects, particularly the risk of dependence, and reports of tinnitus exacerbation upon discontinuation 115 indicate the need for caution, and future research could clarify whether specific patient subgroups might benefit from targeted, short-duration BZD therapy under strict clinical supervision

N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury

In addition, we showed that GSH depletion induces autophagy and SIPS, with autophagy being a negative regulator of SIPS

First, animal model development should prioritize the physiological and behavioral relevance to human tinnitus, incorporating refined induction protocols, cross-species validation, and translational biomarkers measurable in both preclinical and clinical settings