diabetes glutathione depletion at the Crossroads of Redox Homeostasis and Glucose Metabolism in Mellitus | Indian Journal of Clinical Biochemistry Diabetes Type 1 Type 2:

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STING is transported by clathrin-coated vesicles and recycling endosomes (141) and directly encapsulated in lysosomal associated membrane protein 1 (LAMP-1) positive compartments through the ESCRT components tumor susceptibility gene 101 (TSG101) and vacuolar sorting-associated protein 4 (VPS4) (165)

The multi-mechanism approach addresses the complex, multifaceted nature of metabolic regulation more comprehensively than single-pathway interventions

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De Luca and Shoenfeld, 2019