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doi: 10.1093/gerona/glx205

Valproic acid (VPA) is a chemical compound that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, major depression

Further, as detailed above, significant disruption of one-carbon metabolism and nucleotide metabolism is evident in the ndufs2 -/- transcriptomic dataset