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Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease

This results in conformational flexibility of the crossover loop as in the ubiquitin bound structure the crossover loop is displaced away from ubiquitin to make space for the C-terminal tail to thread into the active site ( Figure 6 , red loop)