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Description

Bashar Khalaf, Augusta

10.1002/2211-5463.12577 FEBS Open Bio 119 Martnez-ReyesI.ChandelN

This type of lesion is directly repaired by a suicide enzyme known as MGMT, which removes the methyl group of the DNA base and transfers it to its cysteine residue

This pathway primarily occurs in the liver and kidney and involves four key enzymes: Trimethyllysine Hydroxylase (TMLH), Hydroxytrimethyllysine Aldolase (HTMLA), Trimethylaminobutyraldehyde Dehydrogenase (TMABA-DH), and -Butyrobetaine Hydroxylase (BBOX)