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Result The present study directly evaluated the anti-diabetic effects of isolated marmelosin using standardized biochemical methods and repeated administration in diabetic animal models

Costabile, A., Kolida, S., Klinder, A., Gietl, E., Buerlein, M., Frohberg, C., Landschtze, V., & Gibson, G

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ALDH2 deficiency dramatically slows acetaldehyde conversion, producing toxic accumulation symptoms

Altogether, these data suggest that the Akt/GSK3 and NF-B pathways are involved both in the regulation of CBS activity (as assessed by the decreased H 2 S production 24 h after treatment), but also in the regulation of CBS expression, effect which is observed at the mRNA level 24 h after treatment and at the protein level 48 h after treatment