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During ischemia, hypoxia-induced damage leads in the release of DAMPs, such as high-mobility group box-1 protein (HMGB1) and heat shock proteins (HSPs), which activate pattern recognition receptors (PRRs) such toll-like receptors (TLRs) on immune cells (Fernndez et al., 2020

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thrice weekly) for at least one year prior to the onset of the study], males between the ages of 1835 and a body mass index between 18.525 kg/m 2 completed the double-blind study