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doi: 10.3389/fendo.2017.00060 89

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De Luca LM, et al

Such complexity aims to provide active and adequate protection against bleeding while avoiding excessive and life-threatening thrombosis ( x A 2 ), which are not only necessary for platelet activation by low doses of collagen, but also reactivate platelets and activate the integrin IIb3 via an inside-out signaling pathway ( X A 2 receptor and directly inhibit platelet activation ( X A 2 production in platelets, so platelet activation pathways closely related to T X A 2 secretion, such as P2Y1 and P2Y12-mediated ADP-induced platelet calcium, cAMP, AA, and T X A 2 production, are significantly inhibited ( 50 of 47.0 13.3 M ( X A 2 , P2Y1 and P2Y12 are necessary to maintain IIb3-mediated outside-in platelet activation, and the effect of luteolin on these receptors might affect IIb3-mediated outside-in platelet activation