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Increased collagenase synthesis is characterized by good organization of the epidermal and suprabasal layers, whereas in the control group, during healing, a thin and immature epithelium can be observed for a longer period

To address this gap, we propose the concept of a Dynamic Living Digital Twin framework for precision dosing in critical illness

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Vertical bands involving underlying muscle (platysmal bands) respond less to topical treatment but may still show some improvement in overlying skin texture

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