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Description

Science 260 , 11301132 (1993)

The mice were divided into three groups: group 1 mice fed with control diet (CD), group 2 mice fed with high-fat diet (HFD), and group 3 mice fed with HFD for 12 weeks

Oral administration of 1,000 mg of ascorbic acid to the controls resulted in a rapid increase in plasma ascorbic acid in the first two hours with peaks between 1.80 and 3.5 mg/dL and the urinary concentration of ascorbic acid showed a maximal increase