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The reduction of NOx urinary excretion and the high concentration of nitrotyrosine in the rats plasma and organs exhibited that an interaction between nitric oxide (NO) and ROS could contribute to the pathogenesis of hypertension in BSO-treated rats (Eiserich et al., 1995)

Vitamin E Vitamin E protects lipid molecules in cells and in the blood from oxidative damage and stress (Princen 1995

doi: 10.1016/j.placenta.2015.02.004 14 ZhangCWangYYuYPangYXiaoXHaoL

Conclusion: Our work is the first to identify hepatocyte apoptosis and NLRP3 inflammasome activation as drivers of ILICI

Renal tubular secretion and bile secretion of drugs are examples of potentially saturable processes