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Neuroinflammation was induced via the oral administration of ACR (35 mg/kg/day for 12 days), while GFB and ungerminated extracts were coadministered at 300 mg/kg/day for 12 days

* Correspondence: Yijuan Lin, [email protected] These authors have contributed equally to this work to the work

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Mutations in GNE lead to the neuromuscular disorder, GNE myopathy, characterized by muscle weakness and atrophy, with protein aggregation seen in muscle biopsy samples 3

In addition, short-term administration of rhIGF-1 has been shown to increase glomerular filtration rate and renal plasma flow in patients with end-stage renal disease and in healthy subjects