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According to the Office of Dietary Supplements, the following people are most at risk for thiamine deficiency: Older adults Those dependent on alcohol People with HIV/AIDS People with diabetes Those who have had bariatric surgery Mount Sinai: "Thiamin" National Institutes of Health Office of Dietary Supplements: "Thiamin" Mayo Clinic Laboratories: "Thiamine (Vitamin B1), Whole Blood" America's Poison Centers: "Get online poison help now" PubChem: "Thiamine Hydrochloride - Safety and Hazards" BMJ Case Reports: "Anaphylactic Shock and Cardiac Arrest Caused by Thiamine Infusion" MedlinePlus: Thiamine (Vitamin B1) Lynn Grieger, RDN, CDCES Medical Reviewer Lynn Grieger is a registered dietitian-nutritionist, certified diabetes care and education specialist, certified personal trainer, and certified health and wellness coach

however, large-scale controlled human efficacy data are not yet available

However, researchers in regulated professional contexts (physicians, pharmacists, veterinarians) should be aware that their professional licensing boards may have separate positions on non-approved compounds

ROS mainly includes hydrogen peroxide, hydroxyl radical, singlet oxygen, hypochlorous acids, and superoxide anion, which are crucial triggers of oxidative stress (Poyton et al., 2009