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A second comparison is with the N-terminal copper-binding site of human serum albumin, which uses the sequence Asp-Ala-His-Lys (DAHK) at the N-terminus of the albumin protein to bind copper(II) through the same general N-terminal/histidine/amide-nitrogen coordination geometry

The delicate peptide is now in a solution where it's vulnerable to oxidation and microbial growth

In gout research, liposomal encapsulation of eremantholide C and goyazensolide reduced systemic toxicity while preserving anti-hyperuricemic activity, as evidenced by stabilized SUA reduction and biocompatibility in preclinical models (Ma et al., 2025)