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The human GST multi-gene superfamily is encoding for various ubiquitous cytosolic or soluble, mitochondrial and microsomal as well as peroxisomal homo- and heterodimeric transferases ( S -conjugation generates a less or non-toxic product with improved water solubility, favoring the exportation out of the cell and thereby contributing to DNA damage prevention and protection of the cellular integrity ( Regardless the importance of GST activity for cellular vitality and health, the GST gene cluster is a hotspot for DNA sequence mutations that leads to the expression of active but functionally different GST variant proteins

doi: 10.1038/s41419-022-05173-1 Summary Keywords ferroptosis, hepatocellular carcinoma, chemotherapy, drug resistance, therapy Citation Li X, Meng F, Wang H, Sun L, Chang S, Li G and Chen F (2024) Iron accumulation and lipid peroxidation: implication of ferroptosis in hepatocellular carcinoma