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To address this limitation, the study was re-conducted using an IMR-5 (MNA) xenograft immunodeficient NB mouse model, where a reduced toxicity was observed ( Figures 9A, C )

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Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation