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Hypoxia, C

Identification was supported by specific marker gene expression, including T cells (CD3D, CD3E, TRAC), NK cells (NKG7, GNLY, KLRD1), endothelial cells (PECAM1, CLDN5, RAMP2), myeloid cells (CD68, MARCO, LYZ), epithelial cells (EPCAM, KRT19, CDH1), B cells (CD79A, IGHM, IGHG3), mast cells (KIT, MSA42, GATA2), fibroblasts (DCN, COL1A1, THY1), and smooth muscle cells (MYLK, ACTA2, MYH11) ( Figure 4E )