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Furthermore, they characterized IGF1R5, an sdAb that specifically binds to IGF1Rs at the BBB, serving as a ligand to trigger RMT, effectively delivering therapeutic cargo across the barrier [143]

Our aim was to investigate the effect of UA on the metabolism of endogenous antioxidant glutathione by estimating UA induced changes in the expression of glutamate-cysteine ligase, glutathione peroxidase, glutathione reductase, and glutathione synthetase in J744A.1 mouse macrophage cell line

Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line

In short, the proximal small intestine was flushed with ice cold PBS, opened longitudinally, cut into small pieces and transferred to HBSS (Gibco, 14175-053) containing 10% FCS, DTT (1 mM) and EDTA (2 mM) followed by shaking for 20 min at room temperature