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While mean values for all semen parameters at all time-points remained within the normal ranges and did not meet predefined criteria for a clinically significant change (30%), 2 subjects in the dutasteride group had decreases in sperm count of greater than 90% from baseline at 52 weeks, with partial recovery at the 24-week follow-up

speculated that celastrol and CA may contribute to the treatment of idiopathic pulmonary arterial hypertension (IPAH) by targeting the iron metabolic pathway [76]

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Revisiting 3Rs: Rethinking replacement and new approach methodologies

In summary, moderately elevated BHB could antagonize aortic endothelial injury, potentially by causing H3K9bhb to promote the generation of VEGF in diabetic rats (63)