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Overdosage Topically applied clobetasol propionate ointment can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS)

Activated caspase-1 further converts pro-IL-18 and pro-IL-1 to their mature forms

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Evidence derived from human observational studies, autopsy findings, and experimental models suggests that sustained androgen receptor overstimulation may induce structural, functional, and metabolic alterations that compromise cardiovascular homeostasis ( Cardiovascular pathology represents one of the most clinically relevant consequences of AAS misuse

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