glutathione prevent liver cancer Involvement of peroxidases in the occurrence and development of breast cancers | Journal of Translational Medicine Frontiers | Glutamine's double-edged sword:

Glutathione cn chng oxy ha, bo v t bo, chng lo ha

Discovery of curcumin, a component of golden spice, and its miraculous biological activities

Wu H, Xing K, Lou MF

Data are pooled from three independent experiments ( a f )

They observed that metformin could downregulate the expression of MMP-9/MMP-2 and mTOR while upregulating the expression of protein kinase B and adenosine monophosphate-activated protein kinase (AMPK), thereby inhibiting ovarian granulosa cells dysfunction and promoting their recovery of follicle function ( in vitro studies utilizing human granulosa tumor-derived cell models demonstrates that metformin intervention effectively downregulates multiple components of the LPS-activated inflammatory cascade, including LPS-induced miR-670-3p , NOX2 , NLRP3 , ASC , and GSDMD-N , as well as reducing cellular caspase-1 activity, ROS production, and secretion of inflammatory factors