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Electrolytes were normal with the exception of a calcium level of 8.2 mg/dL

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More recently, gene rearrangements have been reported that give rise to AR versions that lack a functional ligand-binding domain (so-called AR variants (ARvs), making them unresponsive to ADT and constitutively active even in the absence of androgens [36]

Primary culture of mouse tubular cells Primary tubular cells were isolated according to a method previously described 26,27