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In this cycle, vitamin B 12 is a necessary cofactor for methionine synthase, an enzyme involved in the methylation of homocysteine to methionine

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In deficiency cases, intramuscular injections might be used as specialized administration formats

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[6] It did not find an effect of the supplements (B6 alone or in combination with B12 and folic acid) on cognition in older adults (60+ years) without dementia at baseline, compared with a placebo