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Notably, NPCs from ASD-DM exhibited a greater number of differentially expressed genes (DEGs) compared to TD-N (204 downregulated, 174 upregulated) relative to ASD-N (86 genes downregulated, 88 genes upregulated) (Supplementary Figure 3A-C), indicating a more pronounced transcriptomic shift in the ASD-DM neurophenotype

Summary of main points: Copper is a critical component of the mitochondrial electron transport change, affecting production of ATP and Reactive Oxygen Species (ROS)