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For example, homozygous and heterozygous carriers of CYP2C9 gene variant alleles with reduced or no enzyme activity such as deletions would then require lower phenytoin doses to maintain therapeutic levels and to avoid an increased risk of toxicity with high drug doses for that patient prescribed for this anti-seizure drug 2,17

doi: 10.1021/acscentsci.1c00010 26 MataM.SarrionI.ArmengotM.CardaC.MartinezI.MeleroJ