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Insufficiency range (145 to 220 pmol/L): I add B12 supplementation as a Tier 2 supplement

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It inhibits the NF-kappaB signaling pathway (a master regulator of inflammatory gene expression inside cells) and the MAPK pathway (another inflammatory signaling cascade), reducing the production of cytokines that damage follicle cells and disrupt normal hair cycling under conditions of chronic scalp inflammation [1]