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Targeting cardiac stem cell senescence to treat cardiac aging and disease

Medical professionals must evaluate individual health profiles, monitor treatment response, and adjust dosing schedules accordingly

Hypoxia has also been shown to drive the accumulation of mitochondrial Akt, which phosphorylates PDK1 at Thr346, inactivates PDHC, and reinforces the Warburg phenotype, a hallmark of cisplatin resistance [132]

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