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10.1038/s41380-023-02399-z 89 LiY

In patients with HS, splenectomy is the gold standard therapeutic option for severe hematologic phenotype, but indications and long-term cost-effectiveness in moderate to mild HS are not well established (51)

simultaneous mutagenesis of two or more contiguous amino acid positions is done using an oligonucleotide that contains contiguous N,N,G/T triplets, i.e