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Based on this, we previously proposed that the AP2-driven clustering of LRP6 could be an avidity-boosting device that facilitates mutual assembly of signalosome components 11

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Lim WK, Kaur P, Huang H, Jo RS, Ramamoorthy A, Ng LF, Suresh J, Maisha FI, Mathuru AS, Tolwinski NS (2021) Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila