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Warrell et al., 1983

NNMT is expressed at high levels in the liver and is also present in adipose tissue, kidney, brain, lung, heart, and skeletal muscle

Key inclusion criteria included a diagnosis of severe AH per NIAAA criteria and severe AKI defined as uremia, metabolic acidosis, creatinine 4 mg/dL, or requiring RRT (ICA grade 3 criteria)