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greater melanin production means darker skin

Dev Biol 419:6477 Green JM (2014) Current state of herbicides in herbicide-resistant crops

In murine models, intrinsic IRF5 in T cells boosts Th1 and Th17 cytokine production, suppresses Th2 cytokines, and promotes T follicular helper (Tfh) cell differentiation in vivo [5, 25, 41, 42]