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Revisiting resveratrol as an osteoprotective agent: molecular evidence from in vivo and in vitro studies

They found that loss of mitochondrial transcription factor A (TFAM), a pivotal regulator of mitochondrial biogenesis, will block TCA cycle and cause the accumulation of cytoplasmic acetyl-CoA and its derivative malonyl-CoA, promoting mDia2 Kmal

26 Recent literature has characterized GSH and other related metabolic enzymes as vital in protecting cells from ROS 27 through oxidation and reduction (redox) mechanisms