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Heat accelerates all degradation pathways, but with GHK-Cu it also increases the rate of copper-catalyzed oxidation

Some strategies take advantage of differences in GSH concentration to construct GSH-responsive prodrugs by introducing a sulfur bond that, in the presence of GSH, may achieve drug-responsive release at the tumor site and enhance anti-tumor effects

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Contributor Information Chen Gurevitz, Metabolism and Lipids Program, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, One Gustave L