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Curcumin-loaded chitosan and bovine serum albumin NPs effectively increase drug passage across the BBB, promote microglial activation, and accelerate A peptide phagocytosis (Yang et al., 2018)

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for example flotation through a 1.080-1.090 g/ml layer [6] or sedimentation on a two-layer gradient of 1.066 and 1.097 g/ml [7,8]