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Mellado M, Martinez-Munoz L, Cascio G, Lucas P, Pablos JL, Rodriguez-Frade JM

In PCOS granulosa cells, elevated phosphorylation of the pro-apoptotic protein BAX, coupled with suppressed phosphorylation of the anti-apoptotic protein BCL-2, enhances mitochondrial pathway apoptosis, accelerating follicular atresia ( 3.6 Chronic low-grade inflammation Chronic low-grade inflammation have been identified as a central component in the pathogenesis of PCOS, rather than mere accompanying phenomena

doi: 10.1002/rmv.2403 418 AlkafaasSSAbdallahAMHussienAMBedairHAbdoMGhoshSet al

On the contrary, chemotherapeutic drugs have the potential to markedly increase ROS levels, which might result in oxidative stress if ROS generation overwhelms the antioxidant defence of the cell (Bhattacharya 2015)

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