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The second component tracked the natural history of NAFLD progression in adults, encompassing 14 distinct health states including no steatosis, simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, decompensated cirrhosis, hepatocellular carcinoma (HCC), LT, and liver-related or other causes of death

Distinct HSC subpopulations and transcriptional programs may play important roles in the transition from advanced fibrosis to cirrhosis in human NASH

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It is usually, but not always, preceded by the dry form of AMD

Luckily, most people with dry macular degeneration do not progress to more advanced geographic atrophy or the wet form