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The intestines highly proliferative stem cells, transit-amplifying progenitor cells, and post-mitotic differentiated cells continually perform high energy-consuming regenerative, digestive, secretory, and absorptive tasks 70

Pluronic P85 (P85) NPs were found to inhibit MCT1-mediated lactate transport across brain microvascular ECs without significantly affecting GLUT1 function

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It should be noted that articular cartilage is an avascular structure and relatively acellular with a dense and highly charged ECM, 37 which also contributes to the difficult delivery of bioactive components into the target site