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3, 16 10.15761/JTS.1000193 [DOI] [Google Scholar] 126.Gisondi P., Fantuzzi F., Malerba M

Functional links between mucolipin-1 and Ca 2+ dependent membrane trafficking in mucolipidosis IV

Some disorders of intracellular cobalamin metabolism (cblC, cblD-MMA/Hcy, cblF, and cblJ) do not only compromise the synthesis of methylcobalamin, but also the synthesis of adenosylcobalamin, cofactor of the enzyme methylmalonyl-CoA mutase, leading to elevated concentrations of both tHcy and methylmalonic acid (MMA)

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These include: Small scaly spots (most often seen on children) Raised, inflamed patches of red skin covered in thick silvery scales (plaques) Dry skin that may crack and bleed Itching, burning sensations around the patches and possibly soreness around them Finger and toe nails that may be thick, pitted or ridged Painfully swollen and stiff joints Is psoriasis contagious