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Mol Cell 35:479489

Circulating levels of reactive oxidative species and pro-inflammatory cytokines are elevated in type 2 diabetes, especially if there are microvascular or macrovascular complications which can lower GSH levels [5, 22]

Berberine also leverages this pathway, activating the NRF2/HO-1/GPX4 axis to suppress ferroptosis (64)

[3] Alpha Lipoic Acid and Neuropathy ALA is widely studied for its role in managing diabetic neuropathy (DN), particularly due to its antioxidant properties

After the meeting, the FDA will review the votes, discussion and public comments before making a decision on each of the peptides