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74,75 The presence of hypoxic cores, one of the most defining features of a tumor, can provide an ideal niche for anaerobic bacteria such as Clostridium species

Our study demonstrated that Gln deprivation severely inhibited the tumor growth of HCC and PCa both in vivo and in vitro, and this occurs partially through reduced GSH levels, resulting in ROS accumulation

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PubMed Europe PMC Scholia Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the -glutamyl cycle

Mechanistically, TB-500s parent peptide (T4) drives endothelial cell migration, tubule formation, and angiogenesis, processes essential for granulation tissue and perfusion during healing