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But, the schedule can change based on how well the patient is doing and ongoing checks

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As shown in Table 1 and Figure 6, the small molecule inhibitors targeting NNMT can be categorized into SAM-competitive inhibitors, NAM-competitive inhibitors, Dual-substrate-competitive inhibitors and isomerization inhibitors

The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation

Thus, in both folate and vitamin B 12 deficiencies, folate is unavailable to participate in DNA synthesis