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Chen D, Mubeen B, Hasnain A, Rizwan M, Adrees M, Naqvi SAH, Iqbal S, Kamran M, El-Sabrout AM, Elansary HO, Mahmoud E, Alaklabi A, Sathish M, Ud Din G (2022) Role of promising secondary metabolites to confer resistance against environmental stresses in crop plants: current scenario and future perspectives

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In terms of the magnitude of fat mass reduction in controlled research settings: Semaglutide (GLP-1 alone): ~1015% body weight Tirzepatide (GLP-1 + GIP): ~1622% body weight Retatrutide (GLP-1 + GIP + Glucagon): ~2429% body weight (Phase 2 data) This stepwise increase with each additional receptor target is a remarkable demonstration of pharmacological synergy and has driven enormous interest in the triple-agonist research space

Zou R, Wang XB, Chi KY, Huo WM, Wang L, Fan HL

The ASCO guidelines identify duloxetine as the sole recommended treatment for CIPN, particularly in cases associated with oxaliplatin and paclitaxel, due to its proven efficacy in alleviating neuropathic symptoms (Loprinzi et al., 2020