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Graf, H

Additionally, proinflammatory cytokines TNF- and IL-1 were significantly reduced in the substantia nigra, with TNF-/GAPDH and IL-1/-actin ratios lowered by 4.5-fold and 14.1-folds, respectively, compared to untreated MPTP-mouse model

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In the case of the MTHFR gene, that might mean that you create less folate than you should

A notable upregulated protein in dementia compared with CN was glutathione synthetase (GSS) (1.7-fold, p = 0.02)