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Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction

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Sanz-Ortega, J., Vocke, C., Stratton, P., Linehan, W

The progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta leads directly to dopamine deficiency, underpinning the hallmark motor symptoms such as bradykinesia, resting tremor, and rigidity, as well as contributing to nonmotor symptoms including autonomic, mood, and cognitive disorders [2]