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Some individuals may start with weekly injections for a period and then transition to monthly injections for maintenance

Ctgf , Connective tissue growth factor

Curr Opin Neurol 34:213218

Pemetrexed is in a subcategory of antimetabolite drugs called folic acid analogs

When B12 is deficient, demyelination occurs, particularly affecting the spinal cord's posterior columns (responsible for proprioception and vibration sense) and lateral corticospinal tracts (controlling motor function)