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[DOI] [PMC free article] [PubMed] [Google Scholar] 179.Marchesi N., Govoni S., Allegri M

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Studies show that B12 helps decrease homocysteine levels, which may lower the risk of heart disease

IDO is a limiting enzyme in tryptophan metabolism, playing a key role in inducing tolerant DCs (47), Kyn produced by IDO catabolism can act on the aromatic hydrocarbon receptor (AhR) to inhibit the activation of the downstream NF-B signaling pathway (48), and promote the secretion of the cytokines TGF- and IL-10, which in turn promotes the differentiation of Treg (49)